Vitamin B12

Both vegans and non-vegetarians can suffer from B12 deficiencies due to the inability to absorb B12. Deficiencies could be the result of bacterial flora being destroyed by antibiotics or because of deficient intake of bacteria in our unnaturally sterile food.

Vitamin B12 deficiency can occur in anyone at any age. In a random test on 21 diabetics conducted by us, we found that about half of them had B12 deficiency, and none of them were vegan. Of those who were not deficient, some were on B complex supplements, which included vitamin B12.

Vitamin B12 is absorbed by the intrinsic factor in the stomach. High protein from meat and milk force the stomach to produce more acid to digest them. (Proteins are digested mainly in the stomach.) This high acid secretion not only is one of the causes of acidity but also destroys the lining of the stomach so that the intrinsic factor is deficient. Thus vitamin B12 is not absorbed.

When deficiency is due to a lack of intrinsic factor, B12 tablets will not help, and injections are required.

Deficiency due to low intake

Vegans may be able to absorb vitamin B12 but are unlikely to get enough of it on a plant-based diet. This is because of our present day lives which are unnaturally hygienic. Micro organisms naturally available in our food are destroyed or removed due to many reasons like:

  • Irradiation of fruits and vegetables
  • Pesticides used in farming
  • Chlorine or other forms of sanitizing drinking water
  • Washing fruits and vegetables well
  • Preservatives used in packaged food
  • High hygiene levels in our lifestyles
  • Modern day toothpastes with Triclosan which destroy oral bacteria
  • Alcohol consumption
  • Use of the microwave

Hence, even fermented and other foods (eg. idli, dosa, miso, kimchi, sauerkraut, rejeuvela, vegan yogurt, tempeh, natto etc) are not enough to provide vegans with required vitamin B12 levels.

Vitamin B12 deficiency may be less common in the West, especially in the US, where soya milk and other ready-made foods are fortified with vitamin B12. Sometimes people who have come back or are visiting India from the West may develop symptoms after a few months, which they never had in the West. Many people who want to live naturally, are averse to taking vitamin B12 supplements and this may not cause a problem for a number of years, since vitamin B12 can be stored in our body, but sooner or later this problem can catch up. Therefore it is important that everybody keeps a check.

Symptoms of B12 deficiency

Symptoms can range widely and may not manifest themselves at all, because vitamin B12 is required by all cells of the body. Some of the common symptoms of vitamin B12 deficiency are weakness, apathy, memory loss, acidity, loss of weight, nausea and vomiting, anaemia, mental confusion, delusions, paranoia, respiratory symptoms, hives and other symptoms of allergy. A long-term deficiency can lead to heart attacks or stroke—the very problems that a healthy vegan diet can prevent. Long-term vitamin B12 deficiency can cause irreversible damage to the brain and nervous system.

There are 4 main tests for vitamin B12

1. Serum B12—The normal range is 200 to 900 pg/ml. (Please note that your B12 may have been measured by another system – pmol/l so you should see the normal range described in your report.) If your B12 is less than 150 it is very low. A good level is around 400. If a cynocobalamin source is consumed these levels may be high but the B12 is still not usable by the body. In this case its better to rely on one of the other two tests

2. Homocysteine level—High homocysteine levels are an indicator that the usable vitamin B12 is low, and should be supplemented. If Serum B12 levels are normal but homocysteine is high (common in people taking cynocobalamin supplements), a methylcobalamin supplement is necessary.

3. MMA—Methylmalonic Acid, serum: MMA, along with homocysteine, helps diagnose an early or mild B12 deficiency. If MMA and homocysteine levels are increased, then vitamin B12 deficiency may be present, indicating less available B12 at the tissue level. If only homocysteine is elevated, then folic acid may be low or not being metabolism properly. If MMA and homocysteine levels are normal, it is unlikely that there is a B12 deficiency.

4. Holotranscobalamin—this test is not done everywhere and is expensive but it’s the best test because it measures usable B12. Under normal circumstances Its alright to rely on Serum B12 if cynocobalamin supplements are not being taken. Otherwise homocysteine levels are more reliable. Alternatively both serum vitamin B12 and homocysteine levels can be tested.

It is important to take supplements or at least check levels regularly so that supplementation is not delayed. It is better to take just B12 instead of B complex. There are two kinds of vitamin B12 – methylcobalamin and cynocobalamin. Methylcobalamin is the kind which is used by our body. Our body cannot efficiently use cynocobalamin. Spirulina and Chorella contain cynocobalamin and not methylcobalamin, and hence are not good sources of vitamin B12. Some vitamin B complex supplements also contain cynocobalamin rather than methylcobalamin!

Tablets

If deficiency is low and the absorption of vitamin B12 is not yet affected, you could opt to take B12 orally. There are many preparations available in India. Methycobal 500Mcg by Wockhardt is recommended. Other options are Nurokind by Mankind, and Folinext by Otsira genetics. Folinext contains both Folic acid and methylcobalamin. Take one tablet daily initially when the deficiency is detected. After 3 months, get your blood levels checked again and see if levels are normal. Once your blood levels reach normal take one tablet every alternate day for life. In case you are not vegan and your B12 levels are low, it means you are not absorbing B12. In this case the only option is injections.

Injections

Vitamin B 12 injections should be taken if the deficiency is very severe, or you are not vegan but deficient. If you are vegan and deficient, you may be able to absorb, so after the initial injections you could switch to tablets and continue for life or you may chose to take regular injections (about once in two months).  In case you experience some side effects after the injection they should not last for long. Injections should be given to you by a doctor after a test dose for the first time.

Injection Eldervit from Elder Company is recommended. It comes as a combi pack of two vials. No.1. vial contains vitamin B12, 2500mcg with Folic acid 0.7mg, and Niacinamide 12 mg. No.2 vial contains Vitamin C, 150 mg. No. 1 vial can be taken as it is or mixed with no. 2 vial. Mixed is better for absorption of vitamin B12. About 10 injections may be required initially in one month depending upon the severity of deficiency. Later one injection every two months is good as a maintenance dose.

Injection Vitcofol contains B12 and Folic acid. Take a total of 2 vials (each vial 10 ml) in the following way: Take 2ml twice a week of Vitcofol for 15 days. After that, 2ml each week. This should be enough to lift the B12 levels. The second vial would last for one month and one week.

Injection Methycobalamin contains only vitamin B12 but is in the same dosage as the Vitcofol injection and comes in similar sized vials of 10ml each. This can be taken in exactly the same way as you would take Vitcofol. This is not painful. The other one is a little painful.

“Some people prefer to not take vitamin B12 because they feel its unnatural to take any supplements. I was one of them. However I now understand that this rule applies only to people who live in a natural world where they can drink water from the river or pond and the fruits and vegetables grow in their backyard. However everyone should still get their B12 levels checked and make sure they have healthy levels. In some countries foods are fortified and levels may be ok. In others like India, one has to be more careful.” —Dr. Nandita Shah

Vitamin B12 supplements have no known toxicity for all intent and purposes. Too much will not kill, too little can. Therefore it is better to be safe than sorry.

Many vegans avoid taking vitamin B12 because they are fearful that it will contain animal ingredients. This is unlikely because vitamin B12 is made by bacteria. Also, Diana Ratnagar, BWC’s chairperson took the effort of writing to Wockhardt to check about their ‘Methylcobal’. “Methycobal has no animal ingredients and it is not tested on animals” was the firm reply from Wockhardt. Please do not hesitate to take it for this reason.